Futures the Dow Jones Industrials plunged 250 points, or 0.8%, to 30,115.
Futures for the S&P 500 faded 31.5 points, or 0.8%, to 3,771.75.
Futures for the NASDAQ Composite dropped 100 points, or 0.9%, to 11,540.75.
Bionano Genomics saw its shares jumped 11.3% after the company published a study on using optical genome mapping to investigate liver cancer.
Morgan Stanley dipped 1.4%, while Goldman Sachs slid 1.6% after Atlantic Equities downgraded both stocks due to the potential of declining investment banking volume.
General Motors shares dipped 1.8% after Morgan Stanley lowered its price target on the stock.
Meanwhile, a weakening in the most recent job openings data had some investors considering whether the Federal Reserve will slow the pace of interest rate hikes.
Market participants wondered whether those signs could mean markets have finally priced in a bottom after the sharp declines in the prior quarter.
Traders are expecting a raft of economic reports on Wednesday.
Data on weekly mortgage applications is expected. September’s ADP private payrolls showed businesses created 208,000 in September. That number is better than the 200,000 Dow Jones estimate and ahead of the upwardly revised 185,000 in August, according to ADP.
The latest international trade reading is due at 8:30 a.m. ET, while the ISM services index is set to be released at 10 a.m. ET.
In Japan, the Nikkei 225 gained 0.5%, while in Hong Kong, the Hang Seng returned to trading with a massive gain of 5.9%.
Oil prices gained 16 cents to $86.68 U.S. a barrel.
Gold prices stumbled $15.80 to $1,714.70 U.S. an ounce.