We recently compiled a list of the 10 Best Performing Small-Cap Stocks in 2024. In this article, we will look at where Avidity Biosciences Inc. (NASDAQ:RNA) ranks among the best-performing small-cap stocks in 2024.
The Case for Small Caps
The recent Fed rate cut has made the market cautiously optimistic. Despite the unusual timing, historical data suggests a continued upward trend. Recently, we discussed the Dow’s new all-time high. The major stock index recently surpassed its previous peak, closing at a record-breaking level. This surge was fueled by a combination of factors, including positive investor sentiment following a central bank rate cut and broader economic optimism. This record-breaking performance reflects a strong upward trend in the market, indicating robust investor confidence and a favorable economic outlook.
Here’s an excerpt from the article on 10 Best Performing Stocks in 2024:
“The Dow Jones Industrial Average has recently made headlines by closing above the 42,000 mark for the first time, a significant milestone that reflects a surge in investor confidence following a substantial interest rate cut by the Fed. This momentous achievement occurred on September 19, when the Dow jumped over 500 points, closing at 42,063.36. This rise was part of a broader trend in the stock market, with major indices experiencing overall gains throughout the week, largely fueled by optimism surrounding the Fed’s decision to lower interest rates by 0.5%.
On September 21, Edward Yardeni, president of Yardeni Research, while acknowledging that the market tends to keep rising, also discussed the warning signs of a melt-up, in the context of the markets’ response to the September rate cut on CNBC’s ‘Closing Bell’. He doubted the necessity of such a large rate cut, suggesting that the economy is currently growing at about 3% year-over-year and could potentially grow even faster. Yardeni noted that while productivity gains are expected to be more pronounced shortly, he would have preferred to see the market stabilize for a while instead of continuing its upward trajectory.”
Richard Bernstein, CEO of Richard Bernstein Advisers, joined CNBC’s ‘The Exchange’ on September 24 to provide insights on the performance of small-cap stocks. He noted that while small caps have been performing well, they have not kept pace with more speculative investments, such as cryptocurrencies, which have seen significant gains. Bernstein expressed concern that this trend could signal to the Fed that their liquidity measures may have been excessive, as funds are not being directed towards productive uses in the economy.
He elaborated on his bullish stance regarding mid-cap and small-cap stocks, emphasizing that these categories are expected to experience substantial earnings growth. By the end of this year or early next year, Bernstein forecasts that small caps will grow at a rate significantly higher than the MAG 7 tech stocks. He pointed out that this phenomenon is typical when profit cycles hit a trough; small caps tend to be more sensitive to upturns in profitability, and noted the Fed’s current easing policies are occurring simultaneously with an environment of accelerating profits, an unusual combination that could fuel economic growth.
When asked about the current market dynamics favoring mega-cap stocks over smaller ones, Bernstein acknowledged that many managers are indeed gravitating towards these larger companies. However, he cautioned that from a fundamental investment perspective, mega-cap stocks are generally slower-growing and more expensive compared to other market segments. He argued that historically, a combination of cheaper and faster-growing stocks has proven to be advantageous for investors.
Bernstein also discussed the implications of rising gold prices and the performance of cryptocurrencies following recent Fed actions. He distinguished between gold and cryptocurrencies, suggesting that while gold has legitimate economic uses, cryptocurrencies often do not serve productive economic functions. He expressed concern over the speculative fervor in the market, arguing that excessive financial asset inflation can be as detrimental as real asset inflation. This misallocation of capital can lead to inflationary pressures as resources are diverted from essential sectors like infrastructure to less productive areas such as cryptocurrencies.
Overall, Bernstein’s insights reflect a cautious optimism regarding small-cap stocks amidst broader market trends. With that, we’re here with a list of the 10 best-performing small-cap stocks in 2024.
Methodology
We used stock screeners to look for companies trading between $1 billion and $10 billion, that’s our definition of small-cap stocks. We then selected the top 10 stocks with the best year-to-date performance and that were also the most popular among elite hedge funds. The stocks are ranked in ascending order of their year-to-date performance.
Why are we interested in the stocks that hedge funds pile into? The reason is simple: our research has shown that we can outperform the market by imitating the top stock picks of the best hedge funds. Our quarterly newsletter’s strategy selects 14 small-cap and large-cap stocks every quarter and has returned 275% since May 2014, beating its benchmark by 150 percentage points (see more details here).
Avidity Biosciences Inc. (NASDAQ:RNA)
Year-to-Date Performance as of September 23: 388.73%
Market Cap as of September 23: $5.17 billion
Number of Hedge Fund Holders: 31
Avidity Biosciences Inc. (NASDAQ:RNA) a biopharmaceutical company engaged in the delivery of RNA therapeutics. It develops antibody oligonucleotide conjugates (AOC) that are designed to treat diseases previously untreatable with RNA therapeutics, creating RNA-based drugs that can target and correct underlying genetic defects.
In June, Avidity initiated the global Phase 3 HARBORTM trial evaluating del-desiran for myotonic dystrophy type 1 (DM1). The FDA granted del-desiran Breakthrough Therapy designation for DM1 earlier in May.
In August, it reported positive initial data from the Phase 1/2 EXPLORE44™ trial evaluating del-zota (delpacibart zotadirsen), a potential treatment for Duchenne muscular dystrophy (DMD44). Del-zota demonstrated favorable safety and tolerability in 25 participants across two dose levels (5 mg/kg and 10 mg/kg). Enrollment for the EXPLORE44 trial is now complete, and the company plans to enroll additional patients in the EXPLORE44 Open-label Extension study (OLE).
The company also reported positive initial data from the Phase 1/2 FORTITUDE trial evaluating del-brax for facioscapulohumeral muscular dystrophy (FSHD) in this quarter. The trial demonstrated unprecedented and consistent reductions of over 50% in DUX4 regulated genes, trends of functional improvement, and favorable safety and tolerability.
The company faced some challenges and experienced an 11.70% year-over-year decline, due to a rather heavy focus on R&D investment. Management announced plans to unveil its lead target from its precision cardiology program by Q4 2024, indicating an expansion beyond rare neuromuscular diseases into broader therapeutic areas. Such expansions position the company to become a leader in its industry.
Overall RNA ranks 1st on our list of the best-performing small-cap stocks in 2024. While we acknowledge the growth potential of RNA, our conviction lies in the belief that AI stocks hold great promise for delivering high returns and doing so within a shorter timeframe. If you are looking for an AI stock that is more promising than RNA but that trades at less than 5 times its earnings, check out our report about the cheapest AI stock.
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Disclosure: None. This article was originally published on Insider Monkey.